^{Cephalosporins}

 

Spectrum

Cephalexin: Gram-positive and some Gram-negative organisms including Staphylococcus spp.

Pasteurella spp. Proteus mirabilis. Klebsiella spp., and Escherichia coli. and Pseudomonas spp.

are usually resistant.⁵

 

Physicochemical properties

Acidic, hydrophilic.³

 

Distribution^3,4,7

Do not cross the blood-brain barrier (BBB) or enter the eye or the prostate.

Will reach joints, bile and milk.

Will cross the placenta.

 

Pharmacokinetics

Antimicrobial

C_max

Protein
binding

Volume of distribution

Metabolism & elimination

Terminal
half life

Absorption

T_max

Cefazolin Sodium
(1st gen) 
following IM injection.

 

Data not sourced

16-28%²⁵

0.7L/kg²⁵

 

 

Renal²⁵

48 minutes.²⁵

 

 

Not appreciably absorbed orally.²⁵

Bioavailability after S.C. or I.M. injection over 90%.²⁵

30 minutes²⁵

Cefovecin Sodium

(3rd gen)
following SC injection.

In dogs:121+/- 51 µg/ml.²⁵

In cats:141 +/-12 µg/ml.²⁵

 

In dogs: 98.5%.²⁵

In cats: 99.8%.²⁵

 

In dogs:
0.122 L/kg.²⁵

In cats:
0.09 L/kg.²⁵

 

Renal²⁵

In dogs: 133+/-16 hours.25

In cats: 166 +/-18 hours.²⁵

Completely absorbed following S.C. injection.²⁵

In dogs:
6 hours.²⁵

In cats:
2 hours.²⁵

 

Cephalexin
(1st gen)

In dogs:

30 µg/ml.⁶

In cats:

18.7 µg/ml.²⁵

 

20.8%²⁸

Data not sourced.

Renal⁶

1-2 hours.²⁵

Bioavailability 75%.²⁵

In dogs:

1-2 hours.⁶

In cats:

2.6 hours.²⁵

 

Cefpodoxime Proxetil
(3rd gen)

16mg/ml²⁵

82.6²⁸

0.15L/kg²⁵

Renal²⁵

5-6 hours.²⁵

Bioavailability 63% if fasted²⁵

2.2 hours.²⁵